What is the best drug treatment of vitiligo?

Vitiligo (white split air)


Vitiligo is a primary, localized or generalized depigmentation of the skin disease. Is due to local skin pigmentation disorders, skin and hair follicle melanocytes tyrosinase system dysfunction, the apparent lack of epidermal melanocytes, resulting in skin depigmentation Erzhi.
vitiligo though did not affect the health of patients, and no symptoms of pain, but because it often occurs on the face and other exposed parts, which affect the appearance, of beauty, so that patients often feel distressed. Throughout the body can be severe, physical and mental health to patients affected to a certain extent.
multiple Vitiligo is a common skin disease, the incidence rate of 1% to 2%. The deeper the color, the incidence rate. Incidence between men and women rather, occurs in young people, about half of the patients before the age of onset of 20. In recent years, the incidence of vitiligo on the rise, too early age of onset.

[cause]
mostly acquired vitiligo occurred.

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etiology of vitiligo is not fully understood.
are the following possible risk factors:
1, mental nerve of factors. Many vitiligo patients are affected by various environmental stimuli and after the onset of trauma, mood swings, anxiety, nervousness, irritability, depression and other adverse physiological stimulation can lead to the body, disorder of biochemical reactions, induce or exacerbate the disease development. Others believe that vitiligo is a psychosomatic disease.
2, autoimmune factors. Many experts believe that vitiligo is an autoimmune disease, and may be associated with thyroid disease.
3, self-destruction of melanocytes factors
4, tyrosine, copper ions relative lack of
5, genetic factors. Some people think that genetic factors are autosomal dominant, but has not been a consensus, so now only considered to play a certain role of genetic, family members in a vitiligo someone who is a 3-12% chance of vitiligo, If there are any nerves and other psychological factors and autoimmune disease is easy. drugs,drugs question and answers
6, trauma
7, microcirculatory disturbance. Blocked the microcirculation, so that nutrients can not be delivered to the skin site. Normal growth and development of melanocytes, which make the skin bleaching, there vitiligo lesions.
comprehensive view of various theories is generally believed that the disease is a genetic predisposition of the individual, there are several internal and external factors in the performance of the immune function of excited, nervous, mental and endocrine, metabolic function and other aspects of the disorder, leading to enzyme system inhibition or destruction of melanocytes, or the formation of melanosomes in the process of disorder or black, and finally to depigmentation.
mental factors and neurochemical factors in the pathogenesis and may play an important role.
According to clinical observations, psychological factors and the trauma is the main predisposing factors for vitiligo, in summer is a good season this disease.

[clinical]

predilection site of the disease occur in the face, neck, back, trunk and external genitalia and other parts. Any part of the body the skin can occur. Especially the head, face, neck, buttocks, arms and other parts of the most common. Vulnerable to sunlight occurs in the sun and the friction damage and other parts. Perhaps with a certain relationship between exposure to light.

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lesions were mainly pure white, round or irregular depigmentation spots, smooth surface, clear boundary, edge pigmentation increased. White skin on skin sensitive to sunlight than normal, a little sun that is red. After a slow course of the disease, gradually expanding to four weeks, up to a certain degree of convergence or stop the spread of life time. Vitiligo occurs in the face, and its onset time is short, small area, such as to get early treatment, better effect, so early treatment is essential. The main performance of
, local skin milky white spot, the injured area of the hair may be normal, can also be white. The disease usually superficial, if the white spots larger, after exposure in the summer, occasional burning sensation. The etiology is quite complex, in recent years, some people think may be related to immune disorders. It was also found in patients with trace elements, such as copper, zinc and iron content is often low, so that trace elements may be reduced or abnormal metabolism caused by biological activity. In addition, some of vitiligo occurred after exposure to certain chemical substances, or frostbite, eczema, neurodermatitis, psoriasis or discoid lupus erythematosus and other inflammation subsided, the local skin can also occur with vitiligo, the said secondary vitiligo. Part of the diabetes, pernicious anemia, achlorhydria, hyperthyroidism, alopecia areata patients also may be associated with vitiligo. The other is in the spirit of some patients after stimulation by vitiligo. drugs,drugs question and answers
skin possesses a pigment, because presence of melanin in human skin cells. Black, white, yellow, brown, such as different color, because the content of melanin due to a difference. In recent years, proven through research, the incidence of vitiligo is caused due to various factors within the local skin and hair follicle melanin synthesis obstacles. The synthesis of melanin is inseparable from tyrosine and tyrosinase, which is the dietary intake of tyrosine, the tyrosine enzyme synthesis by the body, and its activity but also with some metal elements in copper, zinc and iron are closely related . When melanoma cells tyrosine - tyrosinase system dysfunction or injury, that will affect the metabolism of melanin, which occurs with vitiligo.

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